Graphical AbstractDomains can spread among proteins in a process called domain shuffling and this has been identified as one of the major mechanisms leading to the formation of new proteins throughout evolution. This process has an impact on the topology of protein-protein interaction networks as it may create new hubs and also increase interconnectivity.

In his explanation of the nature of the being of reason, Fr. José de Aguilar, S.J. presents a notion of «objective concept» which is common to both known real beings and beings of reaso...

Le volume offre huit articles sur le scepticisme pyrrhonien. Les essais, de la plume de M. Bonazzi, T. O’Keefe, J. Warren, F. Grgić, H. Thorsrud, S. Marchand, D. E. Machuca et O. Bueno, sont tous en anglais. Précédés d’une préface, d’une notice sur les auteurs et d’une brève introduction, ils sont suivis d’index des noms propres, des passages et des sujets. Chaque contribution est munie d’une bibliographie. Les deux premiers articles sont consacrés à la section des Esquisses Pyrrhoniennes (PH...

Åsa Burman has recently introduced the important notion of telic power and differentiated it from deontic power in an attempt to build a bridge between ideal and non-ideal social ontology. We find Burman’s project promising but we argue that more is to be done to make it entirely successful. First, there is a palpable tension between Burman’s claim that telic power can be ontologically independent of deontic power and her examples, which suggests that these forms of power share the same (...) basis. Second, it is not completely clear how telic power helps non-ideal social ontologists explain oppression, since Burman thinks that both forms of power are transparent to social agents. We offer solutions to both problems. First, we question the thesis that telic power can exist without deontic power. Burman contends that this is possible because some social roles involving telic power can exist independently of institutions, which are––in her opinion––the source of deontic power. Against Burman, we suggest that all social roles involve deontic power, whether or not they are institutional. Second, we argue that while the exercise of deontic power requires a mutual recognition of the social roles of the interacting agents and, therefore, an acceptance of the associated norms, the exercise of telic power does not require acceptance of the relevant norms. This is why invoking telic power is useful in explaining how oppression and injustice can arise. Lastly, we suggest that the relation between teleological normativity and telic power has not been fully clarified by Burman and requires a deeper analysis. (shrink)

We largely agree with Grimwade et al ’s1 conclusion that challenge trial participants may ethically be paid, including for risk. Here, we add further arguments, clarify some points from the perspective of economics and indicate areas where economists can support the development of a framework for ethically justifiable payment. Our arguments apply to carefully constructed and monitored controlled human infection model trials that have been appropriately reviewed and approved. Participants in medical studies perform a service. Outside the domain of research (...) participation, there is nearly universal agreement that workers providing a service should be compensated fairly, and that work involving more discomfort and risk should be compensated more generously. Accordingly, labour regulations impose floors, not caps on compensation. Caps, even if intended to protect against undue inducement, also raise concerns about illegal price-fixing that disadvantages workers. Such limits on payment for egg donors have successfully been challenged in court.i Moreover, caps on compensation may harm everyone at risk of infection, not just potential participants. Insufficient compensation may impede the recruitment of enough suitable subjects, for example, when representativeness of the subject sample is required. Delays in vaccine development not only prolong disruption of social, educational and economic activity but also lead to excess infections and deaths. Unlike paid CHIM participants, individuals exposed to such infection do not accept it voluntarily, are not compensated for it, and are unlikely to receive the level of medical supervision afforded to closely monitored CHIM participants. Payment caps can lead to attempts to circumvent the regulation. For example, many countries …. (shrink)

Arithmetic deals with numbers: but what is the nature of their existence, of their parts, and of their relationship with countable items? These questions nourished a lively debate between the Platonico-Pythagorean tradition (trying to answer them) and the Pyrrhonian tradition (trying to show that these answers were unsatisfactory). The debate lies at the heart of Sextus Empiricus' Against the Arithmeticians. The present book aims at facing the remarkable historical and philosophical questions raised by Sextus' treatise by offering a new translation (...) of it and the first dedicated commentary to it. (shrink)

Wenn eine Kultur etwas als Erfindung akzeptiert, dann hat dieses Etwas bereits den Status einer Tatsache erhalten, die vorhanden ist und auf ihren Nutzen oder auf ihre Funktion hin befragt werden kann. Was aber geschieht davor? Wie gewinnt das Erfundene Wirklichkeit? Wie in der Kunst, wie im Theater, wie in der Literatur und Musik, wie in der Wissenschaft? Und mit welchen Folgen? Die Beiträge in diesem Band beschäftigen sich alle mit einem Moment oder einem bestimmten Modell der Invention. Ausgehend von (...) den jeweils involvierten Medien wird der Versuch unternommen, diese Momente und Modelle zu rekonstruieren. Um etwas über die entsprechenden Inventionen in Erfahrung bringen zu können, werden diese als Ergebnisse oder Effekte von Improvisationsprozessen begriffen: Improvisationen in dem Sinne, dass von einem grundsätzlich offenen Zukunftsspielraum ausgegangen wird, gleichzeitig aber auch davon, dass es ein Umgebungs- und Verfahrenswissen gibt, das im Einzelfall beschrieben werden kann. (shrink)

When an event occurs which involves a change from a state ϕ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\phi $$\end{document} to a state not-ϕ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\phi $$\end{document}, when does the change occur? This is known in the philosophical literature as the problem of the moment of change. I discuss a puzzle based on this problem raised by Sextus Empiricus in Against the Physicists. I compare two lines of solution, one provided by (...) Hans Kamp’s work on the logic of change and the other inspired by Aristotle’s claim that change cannot happen at an instant. I end with a discussion of these solutions vis-à-vis the account of cessation implicatures proposed by Altshuler and Schwarzschild. (shrink)

This book reexamines the birth of quantum mechanics, in particular examining the development of crucial and original insights of Bohr. In particular, it gives a detailed study of the development and the interpretation given to Bohr's Principle of Correspondence. It also describes the role that this principle played in guiding Bohr's research over the critical period from 1920 to 1927.

This paper investigates the link between the consumer perception that a company is socially oriented and the consumer intention to buy products marketed by that company. We suggest that this link exists when at least two conditions prevail: (1) the products sold by that company comply with ethical and social requirements; (2) the company has an acknowledged commitment to protect consumer rights and interests. To test these hypotheses, we conducted a survey among the clients of retail chains offering Fair Trade (...) products. The results show that socially oriented companies can successfully leverage their reputation to market products with high symbolic values. (shrink)

This article analyses how the philosopher Piero Martinetti conceptualizes the survival of a person’s soul after death. Martinetti’s stance is strongly influenced by the philosophy of Plotinus. Martinetti shows that the relation between singularity and multiplicity is expressed in human beings as two different and complimentary perspectives: a fundamental identity in the atemporal dimension of the intelligible life of the spirit and a dynamic tension in the empiric order of the spatio-temporal becoming. Both dimensions express themselves in a finalistic way, (...) attracted from the One who operates in them as a force of harmonization and concentration. The One as Omnitudo realitatis is the cornerstone of Martinetti’s position in regards to the survival of the individual soul after death: a concentration that happens mysteriously, because it transcends the ability of the human mind to understand it – yet, it certainly happens. ≪One thing only we know: what is worth living will live.≫. (shrink)

I discuss two competing theories of the progressive: the theory proposed in Parsons (1980, 1985, 1989, 1990) and the theory proposed in Landman (1992). These theories differ in more than one way. Landman regards the progressive as an intentional operator, while Parsons doesn't. Moreover, Landman and Parsons disagree on what uninflected predicates denote. For Landman, cross the street has in its denotation complete events of crossing the street; the aspectual contribution of English simple past (perfective aspect) is the identity function. (...) For Parsons, both complete and incomplete events of crossing the street can be in the denotation of the base VP; perfective aspect restricts its denotation to the events that culminate. I present a version of ParsonÕs theory that avoids the problems raised by Landman, in particular the problem posed for Parsons by creation verbs. The repaired version and Landman's theory still differ in the way they analyze uninflected verbs. The repaired version and Landman's theory still differ in the way they analyze uninflected predicates. I present evidence from Slavic languages that both theories are needed. Finally, I discuss some evidence that may favor one or the other approach to the semantics of the English progressive. (shrink)

According to the theoretical framework relating hypnosis to attention, baseline attentional functioning in highly hypnotizable individuals should be more efficient than in low hypnotizable individuals. However, previous studies did not find differences in Stroop-like tasks in which the measure indicative of the Stroop interference effect was based on response latencies. This study was designed to determine whether subjects with different levels of hypnotic susceptibility show differences in baseline attentional functioning. To assess this hypothesis, high, medium, and low hypnotizable subjects performed (...) a Stroop task designed to evaluate accuracy performance, before being subjected to hypnotic induction. Results showed that the Stroop interference effect was smaller in high hypnotizable subjects than in low hypnotizable subjects, whereas it was not different between high, and medium hypnotizable subjects. This outcome supports the notion that baseline attentional functioning is related to hypnotic susceptibility. (shrink)

Resumen En este texto se intenta mostrar que la radicalización de la tesis expresada por Platón en el libro X de la República no permite "apreciar" el valor que el filósofo ateniense sabe que posee la poesía, pues ella podría ser un medio para el ejercicio reflexivo si se sirve de la sobriedad que la filosofía propone. Para realizar esta tarea es menester trazar tres puntos sobre los cuales gira este texto: primero, se ubica al lector en la discusión entre (...) poesía y filosofía para comprender el contexto de la crisis entre estos dos factores de la educación en la antigüedad griega; segundo, se aborda la crítica establecida en el libro X sobre la falta de rigor que muestran los poetas en la búsqueda del conocimiento; finalmente se vislumbra o abre una posibilidad interpretativa acerca del interés que puede tener la proposición de una "poesía filosófica" en la obra de Platón.The following text will try to show that radicalization of the thesis expressed by Plato in the book X does not allow "to "estímate" the value that the Athenian philo-sopher knows that poetry possesses, since poetry might be a means for the reflexive exercise if it takes advantage of the sobriety that philosophy proposes. To carry out this task it is necessary to define three points on which this paper will be about: first, the author will inform the reader about the old discussion among poetry and philosophy to understand the context of the crisis between these two forms of teaching; Second, criticism established in the book X on the lack of rigor in the search of knowledge that poets have will be addressed. Finally, the paper glimpses or opens an interpretive possibility about the interest that the proposition of a "philosophical poetry" can have in Plato's work. (shrink)

English summary: The relationship between Jean-Paul Sartre and the left in France and Europe has always been a tense one. This work examines the integration of the figure of Trotsky and his ideas into the broad range of Sartre's discourse and traces its importance for the development of an independent intellectual course with respect to philosophy and politics. German description: Die Beziehung zwischen Jean-Paul Sartre und der Linken in Frankreich und Europa gestaltete sich stets spannungsreich. In der vorliegenden Arbeit wird (...) die Integration der Figur und der Ideen Trotzkis in die diskursive Klaviatur Sartres in Augenschein genommen und deren Bedeutung fur die Entwicklung eines unabhangigen intellektuellen Kurses in philosophischer wie politischer Hinsicht nachgezeichnet. (shrink)

Collapse models predict the spontaneous collapse of the wave function, in order to avoid the emergence of macroscopic superpositions. In their mass-dependent formulation, they claim that the collapse of any system’s wave function depends on its mass. Neutral K, D, B mesons are oscillating systems that are given by Nature as superposition of two distinct mass eigenstates. Thus they are unique laboratory for testing collapse models that are sensitive to the mass. In this paper we derive—for the single mesons and (...) bipartite entangled mesons—the effect of the mass-proportional CSL (Continuous Spontaneous Localization) collapse model on the dynamics on neutral mesons. We compare the theoretical prediction with experimental data from different accelerator facilities. (shrink)

We compute the effect of collapse models on neutrino oscillations. The effect of the collapse is to modify the evolution of the spatial part of the wave function and we will show that this indirectly amounts to a change on the flavor components. For the analysis we use the mass proportional CSL model, and perform the calculation to second order perturbation theory. As we will show, the CSL effect is very small—mainly due to the very small mass of neutrinos—and practically (...) undetectable. (shrink)

First published in 1982, this reissue contains a critical exposition of the views of Frege, Dedekind and Peano on the foundations of arithmetic. The last quarter of the 19th century witnessed a remarkable growth of interest in the foundations of arithmetic. This work analyses both the reasons for this growth of interest within both mathematics and philosophy and the ways in which this study of the foundations of arithmetic led to new insights in philosophy and striking advances in logic. This (...) historical-critical study provides an excellent introduction to the problems of the philosophy of mathematics - problems which have wide implications for philosophy as a whole. This reissue will appeal to students of both mathematics and philosophy who wish to improve their knowledge of logic. (shrink)

The aim of this paper is to describe the lack of equipment in a neighborhood of Palma de Mallorca, Foners in regard to their population. New residents with migration phenomenon presents a situation of inequality that can lead to negative social processes but were offset requirements. The description is carried out in the area intended to be a claim on integration from a multicultural perspective. A collection of data detailing the shortcomings and proposes targets for intervention through a plan of (...) rehabilitation in the territory. (shrink)

Scholarly research largely converges on the argument that trust is of paramount importance to drive economic agents toward mutually satisfactory, fair, and ethically compliant behaviors. There is, however, little agreement on the meaning of trust, whose conceptualizations differ with respect to actors, relationships, behaviors, and contexts. At present, we know much better what trust does than what trust is. In this article, we present an extensive review and analysis of the most prominent articles on trust in market relationships. Using computer-aided (...) content analysis and network analysis methods, we identify key, recurring dimensions that guided the conceptualization of trust in past research, and show how trust can be developed as a multifaceted and layered construct. Our results are an important contribution to a convergence of research toward a shared and common view of the meaning of trust. This process is important to ensure the body of trust research’s internal theoretical consistency, and to provide reliable and common principles for the management of business relationships – a context in which opportunism and imperfect information may induce economic actors to cheat and stray from fair and ethically compliant behaviors. (shrink)

Scholarly research largely converges on the argument that trust is of paramount importance to drive economic agents toward mutually satisfactory, fair, and ethically compliant behaviors. There is, however, little agreement on the meaning of trust, whose conceptualizations differ with respect to actors, relationships, behaviors, and contexts. At present, we know much better what trust does than what trust is. In this article, we present an extensive review and analysis of the most prominent articles on trust in market relationships. Using computer-aided (...) content analysis and network analysis methods, we identify key, recurring dimensions that guided the conceptualization of trust in past research, and show how trust can be developed as a multifaceted and layered construct. Our results are an important contribution to a convergence of research toward a shared and common view of the meaning of trust. This process is important to ensure the body of trust research's internal theoretical consistency, and to provide reliable and common principles for the management of business relationships — a context in which opportunism and imperfect information may induce economic actors to cheat and stray from fair and ethically compliant behaviors. (shrink)

In Italian Sign Language (LIS), when past or future time adverbs are present, the signs for verbs exhibit the same manual configurations whether the sentence reports a past event or a future event. Facts of this kind, also observed for American Sign Language (ASL) and other sign languages, have led some authors (Friedman, among others) to conclude that these languages, on a par with spoken languages like Chinese, lack grammatical tense. Neidle et al. and Jacobowitz and Stokoe have challenged this (...) view for ASL and have argued that ASL sentences contain tense markers. I present some data showing that LIS verbs inflect for tense. I argue, moreover, that the apparent lack of tense inflection when LIS past and future time adverbs are present is due to the fact that these adverbs shift the s-point and that LIS past and future tenses are absolute tenses. I provide a formal account of the LIS tense system based on these assumptions. The account is implemented in Heim’s analysis of tense. (shrink)